Statins that penetrate blood brain barrier








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Abstract For Statins As Neuroprotectants

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Diverse effects of statins in alzheimer

Risk of developing AD. composite of cognitive test scores. neuropathology. However, large double-blind RCTs of pravastatin 13 and simvastatin 14 lasting 3. Based on these observations, we can make several urgent recommendations for future studies investigating the potential link between statin use and AD risk or progression. Similarly, participants in the Rotterdam epidemiological study were less likely to develop AD if they were taking statins, an effect that was not dependent on ApoE genotype 6. A case-control study by Jick and colleagues 1 found that people over 50 who were taking statins had a lower risk of developing dementia. This was addressed by Rockwood et al. Drug treatment of lipid disorders. We included all articles that provided well-controlled studies and clearly interpretable conclusions about this topic. In one study, people with the ApoE4 allele saw less benefit in terms of cholesterol levels from statin treatment than those with the E2 or E3 alleles Indication bias in which a drug is prescribed to treat a condition that is associated with the variable of interest and cessation bias in which some of the observed protective effects of a drug may be due to patients stopping the drug after being diagnosed with a condition have also been suggested as problems that may occur in statin studies J Neurol Neurosurg Psychiatry. The cardiovascular health study. The effects of non-statin LLAs Some observational studies have examined the effects of non-statin compounds that decrease cholesterol levels Table 1. In vivo and in vitro blood-brain barrier transport of 3-hydroxymethylglutaryl coenzyme A HMG-CoA reductase inhibitors. National Center for Biotechnology Information , U.

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The major statins, along with their reported blood-brain barrier The above data on the variability of BBB penetration across statins (Table 3).

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Request PDF on ResearchGate | Statins as Neuroprotectants: A Comparative In Vitro Study of Lipophilicity, Blood-Brain-Barrier Penetration, Lowering of Brain.

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Description: Statins simvastatin, lovastatin, atorvastatin, pravastatin, fluvastatin , analyzed together and divided into more- and less- lipophilic groups. Chronic administration of statins alters multiple gene expression patterns in mouse cerebral cortex. When a large cohort for prevalent dementia, for incident dementia of elderly people was surveyed for overall dementia or AD and the use of statins an aggregate of lovastatin, simvastatin, cerivastatin, atorvastatin, pravastatin, and fluvastatin in and again in , neither statin use at the initial visit nor at follow-up visits correlated with the risk of developing any dementia or AD during the period between the two visits, although statin use was less common among those who already had dementia at the initial visit 8. Lovastatin, but not fluvastatin, efficiently crossed a monolayer of bovine brain microvessel endothelial cells a model for the BBB and was detected in brain extracts of rats receiving the compound One potential effect of statin treatment deserves special mention. Statins atorvastatin, cerivastatin, fluvastatin, pravastatin, simvastatin. analyzed together and other LLAs fibrates, gemfibrozil, colestipol, cholestyramine, acipimox, niacin, nicotinic acid. analyzed separately from statins. Second , future cohort studies should focus on investigating the effects of cholesterol levels and statin use in either the presymptomatic or very mild symptomatic stages of AD and their contribution to modifying the risk of developing frank AD, and they should assess LDL and HDL separately. In one study, people with the ApoE4 allele saw less benefit in terms of cholesterol levels from statin treatment than those with the E2 or E3 alleles We have made a comparative study of 9 statins lovastatin, mevastatin, pravastatin, simvastatin, cerivastatin, atorvastatin, fluvastatin, pitavastatin, and rosuvastatin , analyzing several parameters that could be related to neuroprotection, such as chemical structure, lipophilicity, potential blood-brain-barrier penetration BBB , 3-hydroxymethylglutaryl co-enzyme A reductase inhibition, cholesterol modulation in neurons, glia, and human hepatocyte cell lines, and protection against neurodegeneration caused by tau hyperphosphorylation induced by okadaic acid. Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity.
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